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| 2022-05-17 00:00:00 |
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| Regular Season | ||
| overview | home | away |
| matches | teams | head to head |
| Form | Round | Date | Time | Match | Final Result | 1st HT | 2nd HT | Full Time |
|---|---|---|---|---|---|---|---|---|
| L | 1 | 14.08.2021 | 20:00 | Fortuna Sittard vs. Twente | 2:1 | 0:1 | 2:0 | 2:1 |
| D | 2 | 22.08.2021 | 12:15 | Twente vs. Ajax Amsterdam | 1:1 | 0:0 | 1:1 | 1:1 |
| L | 3 | 28.08.2021 | 18:45 | Cambuur vs. Twente | 2:0 | 0:0 | 2:0 | 2:0 |
| W | 4 | 11.09.2021 | 16:30 | Twente vs. Utrecht | 1:0 | 0:0 | 1:0 | 1:0 |
| W | 5 | 19.09.2021 | 16:45 | Vitesse vs. Twente | 1:4 | 0:2 | 1:2 | 1:4 |
| W | 6 | 23.09.2021 | 21:00 | Twente vs. AZ Alkmaar | 3:1 | 2:1 | 1:0 | 3:1 |
| W | 7 | 26.09.2021 | 14:30 | Heerenveen vs. Twente | 2:3 | 0:2 | 2:1 | 2:3 |
| D | 8 | 01.10.2021 | 20:00 | Groningen vs. Twente | 1:1 | 1:0 | 0:1 | 1:1 |
| D | 9 | 17.10.2021 | 16:45 | Twente vs. Willem II Tilburg | 1:1 | 1:1 | 0:0 | 1:1 |
| L | 10 | 24.10.2021 | 12:15 | Twente vs. NEC Nijmegen | 1:2 | 0:0 | 1:2 | 1:2 |
| L | 11 | 30.10.2021 | 16:30 | PSV Eindhoven vs. Twente | 5:2 | 2:2 | 3:0 | 5:2 |
| W | 12 | 05.11.2021 | 21:00 | Twente vs. Heracles Almelo | 1:0 | 1:0 | 0:0 | 1:0 |
| W | 13 | 20.11.2021 | 19:45 | Sparta Rotterdam vs. Twente | 0:1 | 0:0 | 0:1 | 0:1 |
| D | 14 | 28.11.2021 | 15:30 | Twente vs. Feyenoord | 0:0 | 0:0 | 0:0 | 0:0 |
| W | 15 | 05.12.2021 | 15:30 | Go Ahead Eagles vs. Twente | 1:2 | 1:0 | 0:2 | 1:2 |
| W | 16 | 12.12.2021 | 13:15 | Twente vs. Waalwijk | 2:1 | 2:1 | 0:0 | 2:1 |
| W | 17 | 18.12.2021 | 22:00 | PEC Zwolle vs. Twente | 1:3 | 0:2 | 1:1 | 1:3 |
| D | 18 | 22.12.2021 | 22:00 | Utrecht vs. Twente | 1:1 | 0:1 | 1:0 | 1:1 |
| W | 19 | 15.01.2022 | 21:00 | Twente vs. Heerenveen | 2:0 | 0:0 | 2:0 | 2:0 |
| W | 20 | 22.01.2022 | 22:00 | Willem II Tilburg vs. Twente | 0:1 | 0:1 | 0:0 | 0:1 |
| W | 21 | 05.02.2022 | 22:00 | Twente vs. Vitesse | 3:0 | 2:0 | 1:0 | 3:0 |
| L | 22 | 13.02.2022 | 17:45 | Ajax Amsterdam vs. Twente | 5:0 | 1:0 | 4:0 | 5:0 |
| D | 23 | 20.02.2022 | 15:30 | Twente vs. Go Ahead Eagles | 2:2 | 0:1 | 2:1 | 2:2 |
| W | 24 | 25.02.2022 | 21:00 | Waalwijk vs. Twente | 1:2 | 0:1 | 1:1 | 1:2 |
| W | 25 | 06.03.2022 | 15:30 | Twente vs. Cambuur | 1:0 | 0:0 | 1:0 | 1:0 |
| W | 26 | 13.03.2022 | 21:00 | AZ Alkmaar vs. Twente | 0:1 | 0:0 | 0:1 | 0:1 |
| W | 27 | 19.03.2022 | 21:00 | Twente vs. PEC Zwolle | 1:0 | 1:0 | 0:0 | 1:0 |
| D | 28 | 02.04.2022 | 18:45 | Twente vs. PSV Eindhoven | 3:3 | 3:1 | 0:2 | 3:3 |
| W | 29 | 09.04.2022 | 21:00 | NEC Nijmegen vs. Twente | 0:2 | 0:0 | 0:2 | 0:2 |
| W | 30 | 22.04.2022 | 20:00 | Twente vs. Sparta Rotterdam | 2:0 | 1:0 | 1:0 | 2:0 |
| D | 31 | 30.04.2022 | 20:00 | Heracles Almelo vs. Twente | 1:1 | 1:1 | 0:0 | 1:1 |
| L | 32 | 07.05.2022 | 18:45 | Twente vs. Fortuna Sittard | 1:2 | 1:2 | 0:0 | 1:2 |
| W | 33 | 11.05.2022 | 20:00 | Twente vs. Groningen | 3:0 | 1:0 | 2:0 | 3:0 |
| W | 34 | 15.05.2022 | 14:30 | Feyenoord vs. Twente | 1:2 | 0:2 | 1:0 | 1:2 |